The general use of the
Zantac is a blocker of H2-histamine receptors. The mechanism of action is in the blockade of histamine H2-receptors of parietal cells of gastric mucous membrane layer. This drug inhibits the day and night the secretion of hydrochloric acid, as basal and stimulirovannuyu), reduces the amount of gastric juice caused by the stretching of the stomach with food load and under the action of hormones and biogenic stimulators, such as gastrin, histamine, acetylcholine, пентагастрина, caffeine. Zantac decreases the amount of hydrochloric acid in the gastric juice almost not suppressing "hepatic enzymes associated with zitohroma P450. It does not affect the concentration of gastrin in the blood plasma, the production of mucus. Zantac reduces activity pepsina. This drug used for the treatment and prevention of disease stomach and duodenal ulcers, gastro-intestinal disorders, caused by NSAIDS, heartburn, increased secretion of gastric juice, symptomatic ulcers, ulcers caused by stress, erosive ezofagit, reflux-ezofagit, syndrome Zollinger-Ellison syndrome and other conditions.

Method of application and the direction of
Take it orally or without food. Dose adjustment should be in patients with significantly abnormal liver or kidney function. In addition pills this drug may be administered intramuscularly (IM) or intravenous injection.

Precautions
Zantac effervescent tablets may contain phenylalanine. Tell the doctor if you are pregnant, planning to become pregnant or breast-feeding before taking Zantac. The risk of developing pneumonia may be increased by this medication.

Contraindications
Hypersensitivity, breast-feeding. In patients with hepatic renal failure, liver cirrhosis, acute porphyria (including in history), children under 12 years of age, pregnancy this medication should be administered with caution.

Possible side effect
In addition it is possible allergy (urticaria, skin rashes, swelling of the most common side effects are Zantac constipation, diarrhea, fatigue, headache, insomnia, muscle pain, nausea and vomiting. Rare more serious side effects: agitation, anemia, confusion, depression, easy помятость or bleeding, hallucinations, hair loss, heart rhythm disturbances, visual changes, or jaundice.


Drug interaction
Antacids may decrease the absorption of Zantac, therefore, their use should be separated from 1-2 hours. Alcohol levels may increase, if Zantac be taken at the same time. This treatment also increases the area under the time concentration in the plasma of the curve (AUC) and the concentration of метопролола in blood serum, slows down the absorption of itraconazole and ketoconazole.

Missed dose
If you miss a dose take it when you remember, but if you are already nearing the time of the next reception of your schedule. If this is so the missed dose. Do not attempt to compensate for the missed dose, taking additional one.


Overdose
If you suspect that you have taken too many drugs to seek immediate medical intervention. Symptoms of overdose include lack of coordination, feel dizzy or fainting.

Storage
Save Zantac in a dry place, away from light at room temperature, 15-30 C (59-86 F).

Refusal
We provide only general information about the medicines, which does not cover all directions, possible integration of the drug, or precautionary measures. The information on this site may not be used for self-treatment and self-diagnosis. Any special instructions for a particular patient should be agreed with your health advisor assistance or the doctor in charge of the case. We deny the authenticity of this information and errors it may contain. We do not accept liability for any direct, indirect, special or other consequential damages resulting from any use of the information on this site, as well as the consequences of self-medication.